The ventricles of the brain remain perhaps the largest anatomic structure in the human body without established primary purpose, even though their existence has been known at least since described by Aristotle.We hypothesize that the ventricles help match a stroke volume of arterial blood that arrives into the rigid cranium with an equivalent volum
Proteins with complex architecture as potential targets for drug design: a case study of Mycobacterium tuberculosis.
Lengthy co-evolution of Homo sapiens and Mycobacterium tuberculosis, the main causative agent of tuberculosis, resulted in a dramatically successful pathogen species that presents considerable challenge for modern medicine.The continuous and ever increasing appearance of multi-drug resistant mycobacteria necessitates the identification of novel dru
11-(4-Methylphenyl)-8,9-dihydro-7H-benzo[f]cyclopenta[b]quinolin-10(11H)-one
In the title compound, C23H19NO, the naphthalene ring system and the cyclopent-2-enone ring exhibit planar conformations with Toddler Tops maximum deviations of 0.034 (1) and 0.02 (1) Å, respectively.The 1,4-dihydropyridine ring adopts an envelope conformation with the C atom bearing the p-tolyl ring as the fl